Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Vaccine. 2009 Aug 13;27(37):5142-51. doi: 10.1016/j.vaccine.2009.06.027. Epub 2009 Jun 24.

Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C.

Author information

  • 1Department of Gastroenterology, Hepatology, and Endocrinology, Medical University of Hannover, Germany.

Abstract

We examined the effect of the hepatitis C virus (HCV) peptide vaccine IC41 on HCV-specific T-cell responses and virological relapse rates in patients with chronic HCV genotype 1 infection when added to pegylated interferon plus ribavirin standard therapy. 35 patients received 6 vaccinations with IC41 from weeks 28 to 48 of standard antiviral treatment and were followed-up for another 6 months. IC41 vaccination did not prevent HCV-RNA relapse in patients with ongoing interferon standard treatment but HCV-specific T-cell responses were inducible and were associated with lower relapse rates. An increase of HCV-specific T-cell responses occurred in 73% of patients, responses were more frequent and stronger in patients with sustained virologic response than in patients who relapsed. Optimized vaccine responses may enhance sustained virologic response rates obtained with standard treatment of chronic hepatitis C.

PMID:
19559112
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk