BMB Rep. 2009 Jun 30;42(6):324-30.

Autophagy in neurodegeneration: two sides of the same coin.

Source

College of Life Science and Nano Technology, Department of Biotechnology, Hannam University, Daejeon 305-811, Korea leeja@hnu.kr

Abstract

Autophagy is a bulk lysosomal degradation process important in development, differentiation and cellular homeostasis in multiple organs. Interestingly, neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology and active protein trafficking. A growing body of evidence now suggests that alteration or dysfunction of autophagy causes accumulation of abnormal proteins and/or damaged organelles, thereby leading to neurodegenerative disease. Although autophagy generally prevents neuronal cell death, it plays a protective or detrimental role in neurodegenerative disease depending on the environment. In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases.

PMID:: 19558789; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Korean Society for Biochemistry and Molecular Biology - PDF

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Review Autophagy in the central nervous system: implications for neurodegenerative disorders. [CNS Neurol Disord Drug Targets...]
Review Autophagy in the central nervous system: implications for neurodegenerative disorders.
Xilouri M, Stefanis L. CNS Neurol Disord Drug Targets. 2010 Dec; 9(6):701-19.
Review Autophagy and neurodegeneration. [ACS Chem Biol. 2006]
Review Autophagy and neurodegeneration.
He C, Klionsky DJ. ACS Chem Biol. 2006 May 23; 1(4):211-3.
Review Autophagy in neurodegenerative disease: friend, foe or turncoat? [Trends Neurosci. 2006]
Review Autophagy in neurodegenerative disease: friend, foe or turncoat?
Nixon RA. Trends Neurosci. 2006 Sep; 29(9):528-35. Epub 2006 Jul 20.
Review Review: autophagy in neurodegeneration: firefighter and/or incendiarist? [Neuropathol Appl Neurobiol. 2009]
Review Review: autophagy in neurodegeneration: firefighter and/or incendiarist?
Rami A. Neuropathol Appl Neurobiol. 2009 Oct; 35(5):449-61. Epub 2009 Jun 25.
Review Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration. [Curr Opin Neurobiol. 2008]
Review Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration.
Tooze SA, Schiavo G. Curr Opin Neurobiol. 2008 Oct; 18(5):504-15. Epub 2008 Oct 23.

See reviews... See all...

Cited by 10 PubMed Central articles

Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons. [J Biol Chem. 2011]
Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.
Tiwari M, Lopez-Cruzan M, Morgan WW, Herman B. J Biol Chem. 2011 Mar 11; 286(10):8493-506. Epub 2011 Jan 7.
Review Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. [Mol Brain. 2010]
Review Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes.
Lee SJ, Koh JY. Mol Brain. 2010 Oct 26; 3(1):30. Epub 2010 Oct 26.
Review Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. [Expert Rev Respir Med. 2010]
Review Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.
Ryter SW, Lee SJ, Choi AM. Expert Rev Respir Med. 2010 Oct; 4(5):573-84.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Autophagy in neurodegeneration: two sides of the same coin.
Autophagy in neurodegeneration: two sides of the same coin.
BMB Rep. 2009 Jun 30 ;42(6):324-30.

PubMed
Degradation of 2-methylaniline and chlorinated isomers of 2-methylaniline by Rho...
Degradation of 2-methylaniline and chlorinated isomers of 2-methylaniline by Rhodococcus rhodochrous strain CTM.
J Gen Microbiol. 1991 Aug ;137(8):2033-9.

PubMed
Surface-associated and secreted factors of Streptococcus suis in epidemiology, p...
Surface-associated and secreted factors of Streptococcus suis in epidemiology, pathogenesis and vaccine development.
Anim Health Res Rev. 2009 Jun ;10(1):65-83.

PubMed
Spatial analysis of plague in California: niche modeling predictions of the curr...
Spatial analysis of plague in California: niche modeling predictions of the current distribution and potential response to climate change.
Int J Health Geogr. 2009 Jun 28 ;8:38.

PubMed
Effectiveness of a tinnitus management programme: a 2-year follow-up study.
Effectiveness of a tinnitus management programme: a 2-year follow-up study.
BMC Ear Nose Throat Disord. 2009 Jun 26 ;9:6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: