Trop Med Int Health. 2009 Sep;14(9):1003-10. Epub 2009 Jun 22.

Intermittent preventive treatment of malaria in infants: how does it work and where will it work?

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London School of Hygiene & Tropical Medicine, London, UK. Roly.Gosling@gmail.com

Abstract

We discuss the potential public health impact of IPTi by estimating the cases of malaria, anaemia and hospital admissions likely to be averted in different transmission settings; and we review the mechanism of action, choice of drugs regimens, and the effect on immunity of IPTi. IPTi using an efficacious drug is likely to substantially reduce cases of clinical malaria in moderate to high transmission settings. However, geographical heterogeneity in malaria transmission could hamper rolling out IPTi as a national policy.

PMID:: 19558374; [PubMed - indexed for MEDLINE]

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