Mean changes in individual YMRS line items of patients with an index of manic or mixed episode. aItem range of 0–4 for elevated mood, increased motor activity/energy, sexual interest, sleep, language/thought disorder, appearance, and insight. item range of 0–8 for irritability, speech, content, and disruptive/aggressive behavior (2).
aPooled data from 2 placebo-controlled trials (LOCF). *p < 0.001, †p = 0.002, ‡p = 0.001, §p = 0.003, ||p = 0.006.
Reproduced with permission from Frye MA, Eudicone J, Pikalov A. et al. Aripiprazole efficacy in irritability and disruptive-aggressive symptoms: young mania rating scale line analysis from two, randomized, double-blind, placebo-controlled trials. J Clin Psychopharmacol. 2008;28:243–245.17 Copyright © 2007 Lippincott Williams & Wilkins.