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Nat Genet. 2009 Jul;41(7):766-7. doi: 10.1038/ng0709-766.

TET2 mutations in myelodysplasia and myeloid malignancies.

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  • Department of Pathology, St Jude's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org


The genetic basis of myelodysplasia has long been enigmatic, with few common targets of mutation known. A new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease.

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  • Acquired mutations in TET2 are common in myelodysplastic syndromes. [Nat Genet. 2009]
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