J Am Soc Mass Spectrom. 2009 Sep;20(9):1739-42. Epub 2009 May 29.

Generation of asparagine-linked glycan structure databases and their use.

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BioPharmaSoft, Boston, Massachusetts 02478, USA. h.gao@biopharmasoft.com

Abstract

Asparagine linked glycans (N-glycans) are important in biological processes. Yet, their structural complexity and lack of databases hinder progress in glycomics and glycobiology. We present a way for in silico generation of very large N-glycan structure databases and their use in high throughput composition and primary structure determination of N-glycans attached to peptides, based on CID (collision induced dissociation) MS/MS (tandem mass spectrometric data). The database and the integrated search engine is called Glyquest and is available to the glycomics community.

PMID:: 19556140; [PubMed - indexed for MEDLINE]

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