Source
Department of Obstetrics and Gynaecology, Institute of Clinical Sciences Lund, Lund University Hospital, 221 85 Lund, Sweden. elisabeth.epstein@med.lu.se
Abstract
BACKGROUND:
No large cohort study has examined the risk of endometrial cancer in relation to sun exposure.
METHODS:
A population-based cohort study of 29,508 women who answered a questionnaire in 1990-92, of whom 24,098 responded to a follow-up enquiry in 2000-02. They were followed for an average of 15.5 years.
RESULTS:
Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. We used a multivariate Cox regression analysis adjusting for age and other selected demographic variables to determine the risk of endometrial cancer. Women using sun beds >3 times per year reduced their hazard risk (HR) by 40% (0.6, 95% confidence interval (CI) 0.4-0.9) or by 50% when adjusting for body mass index or physical activity (HR 0.5, 95% CI 0.3-0.9), and those women who were sunbathing during summer reduced their risk by 20% (HR 0.8 95% CI 0.5-1.5) compared with women who did not expose themselves to the sun or to artificial sun (i.e., sun beds).
CONCLUSION:
Exposure to artificial sun by the use of sun beds >3 times per year was associated with a 40% reduction in the risk of endometrial cancer, probably by improving the vitamin D levels during winter.