Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2009 Aug 1;200(3):417-20. doi: 10.1086/600124.

Importance of the epa locus of Enterococcus faecalis OG1RF in a mouse model of ascending urinary tract infection.

Author information

  • 1Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas Medical School, Houston, TX 77030, USA.

Abstract

Previously, TX5179, a disruption mutant of the enterococcal polysaccharide antigen (epa) gene cluster of Enterococcus faecalis strain OG1RF was shown to be attenuated in translocation, biofilm, mouse peritonitis and was more susceptible to polymorphonuclear leukocyte phagocytic killing. Here, wild-type E. faecalis OG1RF and TX5179 strains were tested in a mixed-infection (inoculum, approximately 1:1) mouse urinary tract infection model. Wild-type OG1RF outnumbered TX5179 in the kidneys (P < .001) and bladder (P < .001). In conclusion, the epa locus of E. faecalis OG1RF contributes to murine urinary tract infection and is the first such enterococcal polysaccharide locus shown to be important in this site.

PMID:
19545208
[PubMed - indexed for MEDLINE]
PMCID:
PMC3615707
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk