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ACS Nano. 2009 Jun 23;3(6):1357-64. doi: 10.1021/nn900277t.

Characterization of antiplatelet properties of silver nanoparticles.

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  • 1Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Abstract

Thrombotic disorders have emerged as serious threat to society. As anticoagulant and thrombolytic therapies are usually associated with serious bleeding complications, the focus has now shifted to regulating and maintaining platelets in an inactive state. In the present study we show that nanosilver has an innate antiplatelet property and effectively prevents integrin-mediated platelet responses, both in vivo and in vitro, in a concentration-dependent manner. Ultrastructural studies show that nanosilver accumulates within platelet granules and reduces interplatelet proximity. Our findings further suggest that these nanoparticles do not confer any lytic effect on platelets and thus hold potential to be promoted as antiplatelet/antithrombotic agents after careful evaluation of toxic effects.

PMID:
19545167
[PubMed - indexed for MEDLINE]
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