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J Phys Chem B. 2009 Jul 16;113(28):9379-85. doi: 10.1021/jp903341u.

Sequence-directed organization of beta-peptides in self-assembled monolayers.

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  • 1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

Abstract

The sequence-directed organization of self-assembled monolayers of amphiphilic beta-peptides adsorbed on gold surfaces is studied using Monte Carlo simulations. A phenomenological model is presented in which each (helical) molecule is represented by a rigid nanorod; side groups are placed at appropriate locations. This model can distinguish between globally amphiphilic (GA) and nonglobally amphiphilic (iso-GA) sequence isomers. The simulations show that the GA isomers have a high degree of orientational order that is not exhibited by the iso-GA isomers, which is consistent with experiment (Pomerantz et al. Chem. Mater. 2007, 19, 4436). The effect of surface coverage and relative strength of electrostatic, hydrophilic, and hydrophobic interactions on the self-assembly of beta-peptides is quantified.

PMID:
19545127
[PubMed - indexed for MEDLINE]

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