Abstract
Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-beta-rhamnopyranosyl (1-->6)-beta-D-glucopyranoside (1) and 4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), beta-sitosterol (4), sitosterol 3-O-beta-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Kaempferols / chemistry
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Kaempferols / isolation & purification*
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Kaempferols / pharmacology
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Magnoliopsida / chemistry*
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Molecular Structure
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Niacin / chemistry
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Niacin / isolation & purification
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Niacin / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry
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Xanthine Oxidase / metabolism*
Substances
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4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone
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Enzyme Inhibitors
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Glucosides
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Kaempferols
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kaempherol 3-O-beta-rhamnopyranosyl (1-6)-beta-D-glucopyranoside
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Niacin
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Xanthine Oxidase