Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii

Yao Xue Xue Bao. 2009 Apr;44(4):390-4.

Abstract

Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-beta-rhamnopyranosyl (1-->6)-beta-D-glucopyranoside (1) and 4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), beta-sitosterol (4), sitosterol 3-O-beta-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Kaempferols / chemistry
  • Kaempferols / isolation & purification*
  • Kaempferols / pharmacology
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • Niacin / chemistry
  • Niacin / isolation & purification
  • Niacin / pharmacology
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry
  • Xanthine Oxidase / metabolism*

Substances

  • 4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone
  • Enzyme Inhibitors
  • Glucosides
  • Kaempferols
  • kaempherol 3-O-beta-rhamnopyranosyl (1-6)-beta-D-glucopyranoside
  • Niacin
  • Xanthine Oxidase