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Drug Discov Today. 2009 Sep;14(17-18):851-8. doi: 10.1016/j.drudis.2009.06.001. Epub 2009 Jun 21.

siRNAs: their potential as therapeutic agents--Part I. Designing of siRNAs.

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  • 1Section of Infectious Diseases & Immunobiology, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad-500007, AP, India.


RNA interference (RNAi) is a novel and essential biological process, as well as a powerful experimental tool with the potential to be used in therapeutic development. RNAi-based strategies have the capability of being able to be driven from bench to bedside. It is very important to develop the precise tools for designing the siRNAs to get the most efficient knockdown of the target genes and to reduce any off-target effects. In this review we have discussed the strategies and parameters required for effective siRNA designing and synthesis, based on already published literature.

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