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Trends Immunol. 2009 Jul;30(7):306-12. doi: 10.1016/j.it.2009.03.013. Epub 2009 Jun 18.

CD28(-) T cells: their role in the age-associated decline of immune function.

Author information

  • 1Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Wengn@mail.nih.gov

Abstract

The accumulation of CD28(-) T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T-cell activation, proliferation and survival of T cells. CD28(-) T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28(-) T cells in comparison to their CD28(+) counterparts and corroborate their functional differences. Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function.

PMID:
19540809
[PubMed - indexed for MEDLINE]
PMCID:
PMC2801888
Free PMC Article
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