Neurosci Lett. 2009 Sep 18;461(2):177-80. Epub 2009 Jun 17.

SORL1 is genetically associated with Alzheimer disease in a Japanese population.

Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M.

Source

Department of Psychiatry, Osaka General Medical Center, Osaka, Japan. kimura@psy.med.osaka-u.ac.jp

Abstract

A recent study reported that variants of the neuronal sortilin-related receptor gene (SORL1) increased the risk of late-onset Alzheimer disease (AD) in several populations. Here, we examined the risk effect in a large, well-characterized group of 437 late-onset AD patients and 451 control subjects in a Japanese population. Among eight single-nucleotide polymorphisms (SNPs) of the SORL1 gene for which association has been reported, we found a significant association for four of them, located between exon 24 and intron 37. This risk was evident in non-carriers of the apolipoprotein E-epsilon 4 allele, but not in its carriers. Our results support the evidence that genetic variants of SORL1 affect susceptibility to late-onset AD.

PMID:: 19539718; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. [Dement Geriatr Cogn Disord. 2008]
Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population.
Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Dement Geriatr Cogn Disord. 2008; 26(2):161-4. Epub 2008 Aug 6.
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. [Hum Mutat. 2008]
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
Bettens K, Brouwers N, Engelborghs S, De Deyn PP, Van Broeckhoven C, Sleegers K. Hum Mutat. 2008 May; 29(5):769-70.
Implication of sex and SORL1 variants in italian patients with Alzheimer disease. [Arch Neurol. 2009]
Implication of sex and SORL1 variants in italian patients with Alzheimer disease.
Cellini E, Tedde A, Bagnoli S, Pradella S, Piacentini S, Sorbi S, Nacmias B. Arch Neurol. 2009 Oct; 66(10):1260-6.
Review The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. [Curr Neurol Neurosci Rep. 2008]
Review The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
Lee JH, Barral S, Reitz C. Curr Neurol Neurosci Rep. 2008 Sep; 8(5):384-91.
Review Very low density lipoprotein receptor in Alzheimer disease. [Microsc Res Tech. 2000]
Review Very low density lipoprotein receptor in Alzheimer disease.
Helbecque N, Amouyel P. Microsc Res Tech. 2000 Aug 15; 50(4):273-7.

See reviews... See all...

Cited by 6 PubMed Central articles

Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways. [Int J Alzheimers Dis. 2011]
Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways.
Olgiati P, Politis AM, Papadimitriou GN, De Ronchi D, Serretti A. Int J Alzheimers Dis. 2011; 2011:832379. Epub 2011 Dec 10.
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. [Ann Neurol. 2011]
SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel JP, Hazrati LN, Palotás A, Lantigua R, Medrano M, Z Jiménez-Velázquez I, et al. Ann Neurol. 2011 Jan; 69(1):47-64.
Meta-analysis of the association between variants in SORL1 and Alzheimer disease. [Arch Neurol. 2011]
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, et al. Arch Neurol. 2011 Jan; 68(1):99-106.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

SORL1 is genetically associated with Alzheimer disease in a Japanese population.
SORL1 is genetically associated with Alzheimer disease in a Japanese population.
Neurosci Lett. 2009 Sep 18 ;461(2):177-80. Epub 2009 Jun 17 .

PubMed
Hospital utilization and readmission rates for geriatric and young adult patient...
Hospital utilization and readmission rates for geriatric and young adult patients with major depression: results from a historical cohort study.
J Geriatr Psychiatry Neurol. 1991 Jul-Sep ;4(3):166-72.

PubMed
Polymorphisms in Toll-like receptor genes and susceptibility to infections in al...
Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.
Exp Hematol. 2009 Sep ;37(9):1022-9. Epub 2009 Jun 17 .

PubMed
Othello syndrome secondary to right cerebrovascular infarction.
Othello syndrome secondary to right cerebrovascular infarction.
J Geriatr Psychiatry Neurol. 1991 Jul-Sep ;4(3):160-5.

PubMed
Field investigation on the repellent activity of some aromatic plants by traditi...
Field investigation on the repellent activity of some aromatic plants by traditional means against Anopheles arabiensis and An. pharoensis (Diptera: Culicidae) around Koka, central Ethiopia.
Acta Trop. 2009 Oct ;112(1):38-42. Epub 2009 Jun 17 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: