Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunity. 2009 Jun 19;30(6):766-75. doi: 10.1016/j.immuni.2009.06.004.

Approaching the asymptote: 20 years later.

Author information

  • Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

The pattern recognition theory proposed by the late Charles Janeway, Jr. 20 years ago provided a conceptual framework for our current understanding of the innate immune recognition and its role in the activation of adaptive immunity. Discovery of several families of pattern recognition receptors and their roles in mammalian immunity provided experimental support for the Janeway's theory. In addition to pattern recognition, there are other forms of innate immune sensing, which presumably work in specific combinations depending on the pathogen class and the type of the immune response they elicit. Here, the development of the Janeway's theory is discussed in the context of the advances made in field of innate immune recognition over the past two decades.

PMID:
19538928
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk