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Cell Cycle. 2009 Jul 1;8(13):2041-9. Epub 2009 Jul 27.

Regulation of the anaphase-promoting complex by the COP9 signalosome.

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  • 1Core Unit Chip Application, Institute of Human Genetics and Anthropology, Jena University Hospital, Jena, Germany.

Abstract

The COP9 complex (signalosome) is a known regulator of the proteasome/ubiquitin pathway. Furthermore it regulates the activity of the cullin-RING ligase (CRL) families of ubiquitin E3-complexes. Besides the CRL family, the anaphase-promoting complex (APC/C) is a major regulator of the cell cycle. To investigate a possible connection between both complexes we assessed interacting partners of COP9 using an in vivo protein-protein interaction assay. Hereby, we were able to show for the first time that CSN2, a subunit of the COP9 signalosome, interacts physically with APC/C. Furthermore, we detected a functional influence of the COP9 complex regarding the stability of several targets of the APC/C. Consistent with these data we showed a genetic instability of cells overexpressing CSN2.

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PMID:
19535905
[PubMed - indexed for MEDLINE]
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