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RNA. 2009 Aug;15(8):1433-42. doi: 10.1261/rna.1703809. Epub 2009 Jun 17.

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.

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  • 1Department of Biochemistry, Max Planck Institute for Developmental Biology, D-72076 Tübingen, Germany.


GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.

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