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    Aust N Z J Med. 1991 Aug;21(4):454-6.

    POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report.

    Source

    Department of Medicine, University of Malaya, Kuala Lumpur.

    Abstract

    Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes are often the presenting features of the POEMS syndrome. Approximately 50% of these are associated with osteosclerotic myeloma, a rare variant of multiple myeloma and some with Castleman's disease, an unusual lympho-proliferative disorder. The underlying pathogenetic mechanisms have not been elucidated but amelioration of symptoms with the disappearance of the M-component suggests possible etiopathogenic mechanisms. We present a 40-year-old woman with manifestations of all three disorders.

    PMID:
    1953537
    [PubMed - indexed for MEDLINE]

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