Recent advances in the development of polyamine analogues as antitumor agents

J Med Chem. 2009 Aug 13;52(15):4551-73. doi: 10.1021/jm900187v.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Biogenic Polyamines / physiology
  • Breast Neoplasms / drug therapy
  • DNA / metabolism
  • Drug Discovery*
  • Eflornithine / therapeutic use
  • Enzyme Inhibitors / therapeutic use
  • Histone Deacetylase Inhibitors
  • Histone Demethylases
  • Homeostasis
  • Humans
  • Oxidoreductases, N-Demethylating / antagonists & inhibitors
  • Polyamines / chemistry
  • Polyamines / pharmacology*
  • Polyamines / therapeutic use
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Biogenic Polyamines
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Polyamines
  • DNA
  • Histone Demethylases
  • KDM1A protein, human
  • Oxidoreductases, N-Demethylating
  • Eflornithine