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World J Gastroenterol. 2009 Jun 21;15(23):2855-61.

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

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  • 1Department of Pediatrics, Children's Hospital, University of Texas Medical Branch, Galveston, TX 77555, United States. ejbeswic@utmb.edu


CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

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