Pediatr Res. 2009 Sep;66(3):301-5.

Spontaneous brain activity in the newborn brain during natural sleep--an fMRI study in infants born at full term.

Fransson P, Skiöld B, Engström M, Hallberg B, Mosskin M, Aden U, Lagercrantz H, Blennow M.

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Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, Stockholm, Sweden. Peter.Fransson@ki.se

Abstract

Recent progress in functional neuroimaging research has provided the opportunity to probe at the brain's intrinsic functional architecture. Synchronized spontaneous neuronal activity is present in the form of resting-state networks in the brain even in the absence of external stimuli. The objective of this study was to investigate the presence of resting-state networks in the unsedated infant brain born at full term. Using functional MRI, we investigated spontaneous low-frequency signal fluctuations in 19 healthy full-term infants. Resting-state functional MRI data acquired during natural sleep was analyzed using independent component analysis. We found five resting-state networks in the unsedated infant brain born at full term, encompassing sensory cortices, parietal and temporal areas, and the prefrontal cortex. In addition, we found evidence for a resting-state network that enclosed the bilateral basal ganglia.

PMID:: 19531974; [PubMed - indexed for MEDLINE]

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Spontaneous brain activity in the newborn brain during natural sleep--an fMRI study in infants born at full term.

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