Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Transl Oncol. 2009 Jun;11(6):349-55.

The role of antiangiogenesis therapy: bevacizumab and beyond.

Author information

  • 1Hospital Universitario 12 de Octubre, ES-28041 Madrid, Spain. hcortes.hdoc@salud.madrid.org

Abstract

The importance of angiogenesis in tumour growth and development is well known. Overexpression of vascular endothelial growth factor (VEGF), the key mediator of angiogenesis, is associated with poor prognosis in cancer. As a result, several therapeutic agents that inhibit the actions of VEGF or its receptors are currently in development for use in advanced solid tumours, such breast, colorectal, lung and renal cancer. Clinical data from trials of anti-VEGF agents in this group of tumours are discussed, with a particular focus on the efficacy and safety of bevacizumab, the anti-VEGF agent at the most advanced stage of development in those tumour types. Future potential uses of bevacizumab in cancer therapy will be discussed.

PMID:
19531449
[PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk