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Ann Intern Med. 2009 Jun 16;150(12):821-9, W145-6.

Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial.

Author information

  • 1National Institutes of Health, Hatfield Clinical Research Center, Bethesda, Maryland 20892-1103, USA. jy15i@nih.gov

Abstract

BACKGROUND:

Some data suggest that increasing calcium intake may help prevent weight gain.

OBJECTIVE:

To test the hypothesis that calcium supplementation can prevent weight gain in persons who are overweight or obese.

DESIGN:

Randomized, placebo-controlled trial. Randomization was computer-generated, and allocation was assigned by pharmacy personnel who prepared intervention and placebo capsules. Participants, providers, and those who assessed outcomes were blinded to study group assignment.

SETTING:

Single research center.

PARTICIPANTS:

340 overweight (body mass index [BMI], 25 to <30 kg/m(2)) and obese (BMI > or =30 kg/m(2)) adults (mean age, 38.8 years [SD, 10.5]).

INTERVENTION:

Calcium carbonate (elemental calcium, 1500 mg/d) (n = 170) or placebo (n = 170) with meals for 2 years.

MEASUREMENTS:

Changes in body weight and fat mass (primary outcomes).

RESULTS:

Seventy-five percent of participants completed the trial (78% received calcium; 73% received placebo). There were no statistically or clinically significant differences between the calcium and placebo groups in change in body weight (difference, 0.02 kg [95% CI, -1.64 to 1.69 kg]; P = 0.98), BMI (difference, 0.32 kg/m(2) [CI, -0.41 to 1.02 kg/m(2)]; P = 0.39), or body fat mass (difference, 0.39 kg [CI, -1.04 to 1.92 kg]; P = 0.55). Parathyroid hormone concentrations decreased in the calcium group compared with the placebo group (difference, -0.71 pmol/L [CI, -1.28 to -0.13 pmol/L]).

LIMITATION:

The study took place at a research center, and its sample was mostly women.

CONCLUSION:

Dietary supplementation with elemental calcium, 1500 mg/d, for 2 years had no statistically or clinically significant effects on weight in overweight and obese adults. Calcium supplementation is unlikely to have clinically significant efficacy as a preventive measure against weight gain in such patients.

Summary for patients in

PMID:
19528561
[PubMed - indexed for MEDLINE]
PMCID:
PMC2698127
Free PMC Article
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