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    Antimicrob Agents Chemother. 2009 Aug;53(8):3515-9. Epub 2009 Jun 15.

    Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.

    Wolff KA, Nguyen HT, Cartabuke RH, Singh A, Ogwang S, Nguyen L.

    Source

    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106-4960, USA.

    Abstract

    Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.

    PMID:
    19528288
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2715596
    Free PMC Article

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