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Dev Biol. 2010 Mar 15;339(2):258-66. doi: 10.1016/j.ydbio.2009.06.012. Epub 2009 Jun 13.

Nucleosome positioning: how is it established, and why does it matter?

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  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.


Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA. The positioning of nucleosomes on underlying DNA plays a key role in the regulation of these processes, as the nucleosome occludes underlying DNA sequences. Here, we review the literature on mapping nucleosome positions in various organisms, and discuss how nucleosome positions are established, what effect nucleosome positioning has on control of gene expression, and touch on the correlations between chromatin packaging, sequence evolution, and the evolution of gene expression programs.

Copyright 2009 Elsevier Inc. All rights reserved.

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