An analysis of Jimi Hendrix's guitar playing and song writing is presented in light of the effects of his mixed-right-handedness on motoric and conceptual processing. It is argued that (i) his mixed-handedness allowed him greater integration of the roles of his left and right hands in guitar playing and (ii) his right-handedness conferred specific benefits in playing a left-handed guitar. In terms of his song writing, the greater interhemispheric interaction (and consequent greater access to right hemisphere processing) associated with mixed-handedness is argued to characterise aspects of his lyrics and vocal delivery.