Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Methods. 2009 Jul;6(7):511-2. doi: 10.1038/nmeth.1339. Epub 2009 Jun 14.

In vivo fluorescence imaging with high-resolution microlenses.

Author information

  • 1James H Clark Center for Biomedical Engineering and Sciences, Stanford University, Stanford, California, USA.

Abstract

Micro-optics are increasingly used for minimally invasive in vivo imaging, in miniaturized microscopes and in lab-on-a-chip devices. Owing to optical aberrations and lower numerical apertures, a main class of microlens, gradient refractive index lenses, has not achieved resolution comparable to conventional microscopy. Here we describe high-resolution microlenses, and illustrate two-photon imaging of dendritic spines on hippocampal neurons and dual-color nonlinear optical imaging of neuromuscular junctions in live mice.

PMID:
19525959
[PubMed - indexed for MEDLINE]
PMCID:
PMC2849805
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk