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    Clin Lymphoma Myeloma. 2009 Jun;9(3):206-16.

    Hodgkin lymphoma: an update on its biology with new insights into classification.

    Mani H, Jaffe ES.

    Source

    Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

    Abstract

    In the past few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma (HL). In standard texts, HL is classified as 2 distinct entities, namely nodular lymphocyte-predominant HL and classical HL (CHL). However, recent evidence suggests that CHL is not a single disease. Although the mixed cellularity and lymphocyte-depleted subtypes might be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation, and histology. Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review.

    PMID:
    19525189
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2806063
    Free PMC Article

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