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Biochem Biophys Res Commun. 2009 Aug 14;386(1):263-7. doi: 10.1016/j.bbrc.2009.06.038. Epub 2009 Jun 11.

Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo.

Author information

  • 1Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-4130, USA. kanungoj@mail.nih.gov

Abstract

Cyclin-dependent kinase 5 (cdk5) is a ubiquitous protein activated by specific activators, p35 and p39. Cdk5 regulates neuronal migration, differentiation, axonogenesis, synaptic transmission and apoptosis. However, its role in motor neuron development remains unexplored. Here, using gain and loss-of-function analyses in developing zebrafish embryos, we report that cdk5 plays a critical role in spinal and cranial motor neuron development. Cdk5 knockdown results in supernumerary spinal and cranial motor neurons. While a dominant negative, kinase-dead cdk5 promotes the generation of supernumerary motor neurons; over-expression of cdk5 suppresses motor neuron development. Thus, modulating cdk5 activity seems promising in inducing motor neuron development in vivo.

PMID:
19523926
[PubMed - indexed for MEDLINE]
PMCID:
PMC2758157
Free PMC Article
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