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Clin Infect Dis. 2009 Jul 15;49(2):279-90. doi: 10.1086/600035.

Human infection with highly pathogenic avian influenza A (H5N1) virus: review of clinical issues.

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  • 1Epidemiology and Prevention Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.


This article provides an updated review of the clinical issues related to human infection with highly pathogenic avian influenza A (H5N1) virus. The clinical data available to date are presented, as well as recent findings on the pathogenesis of and antiviral treatment and immunotherapy for H5N1 virus infection in humans and animal models.

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