Nat Rev Immunol. 2009 Jul;9(7):465-79.

Signalling through C-type lectin receptors: shaping immune responses.

Source

Academic Medical Center, University of Amsterdam, The Netherlands. t.b.geijtenbeek@amc.uva.nl

Abstract

C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates. Some CLRs can induce signalling pathways that directly activate nuclear factor-kappaB, whereas other CLRs affect signalling by Toll-like receptors. Dissecting these signalling pathways and their effects on host immune cells is essential to understand the molecular mechanisms involved in the induction of adaptive immune responses. In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches.

PMID:: 19521399; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Review Innate signaling and regulation of Dendritic cell immunity. [Curr Opin Immunol. 2007]
Review Innate signaling and regulation of Dendritic cell immunity.
van Vliet SJ, den Dunnen J, Gringhuis SI, Geijtenbeek TB, van Kooyk Y. Curr Opin Immunol. 2007 Aug; 19(4):435-40. Epub 2007 Jul 12.
Review C-type lectins on dendritic cells: key modulators for the induction of immune responses. [Biochem Soc Trans. 2008]
Review C-type lectins on dendritic cells: key modulators for the induction of immune responses.
van Kooyk Y. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1478-81.
Review Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions. [Immunobiology. 2011]
Review Targeting Syk-Card9-activating C-type lectin receptors by vaccine adjuvants: findings, implications and open questions.
Lang R, Schoenen H, Desel C. Immunobiology. 2011 Nov; 216(11):1184-91. Epub 2011 Jun 21.
Review Self- and nonself-recognition by C-type lectins on dendritic cells. [Annu Rev Immunol. 2004]
Review Self- and nonself-recognition by C-type lectins on dendritic cells.
Geijtenbeek TB, van Vliet SJ, Engering A, 't Hart BA, van Kooyk Y. Annu Rev Immunol. 2004; 22:33-54.
Review Pathogens use carbohydrates to escape immunity induced by dendritic cells. [Curr Opin Immunol. 2004]
Review Pathogens use carbohydrates to escape immunity induced by dendritic cells.
van Kooyk Y, Engering A, Lekkerkerker AN, Ludwig IS, Geijtenbeek TB. Curr Opin Immunol. 2004 Aug; 16(4):488-93.

See reviews... See all...

Cited by 42 PubMed Central articles

The role of heat shock proteins in antigen cross presentation. [Front Immunol. 2012]
The role of heat shock proteins in antigen cross presentation.
Murshid A, Gong J, Calderwood SK. Front Immunol. 2012; 3:63. Epub 2012 Mar 30.
Cell receptors for influenza a viruses and the innate immune response. [Front Microbiol. 2012]
Cell receptors for influenza a viruses and the innate immune response.
Ramos I, Fernandez-Sesma A. Front Microbiol. 2012; 3:117. Epub 2012 Mar 28.
Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e. [PLoS One. 2012]
Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e.
Thiyagarajan D, Fismen S, Seredkina N, Jacobsen S, Elung-Jensen T, Kamper AL, Fenton CG, Rekvig OP, Mortensen ES. PLoS One. 2012; 7(3):e34080. Epub 2012 Mar 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Signalling through C-type lectin receptors: shaping immune responses.
Signalling through C-type lectin receptors: shaping immune responses.
Nat Rev Immunol. 2009 Jul ;9(7):465-79.

PubMed
Prevalence of obesity among children with chronic conditions.
Prevalence of obesity among children with chronic conditions.
Obesity (Silver Spring). 2010 Jan ;18(1):210-3. Epub 2009 Jun 11 .

PubMed
The current state of cancer family history collection tools in primary care: a s...
The current state of cancer family history collection tools in primary care: a systematic review.
Genet Med. 2009 Jul ;11(7):495-506.

PubMed
Dehydroepiandrosterone pretreatment alters the ischaemia/reperfusion-induced VEG...
Dehydroepiandrosterone pretreatment alters the ischaemia/reperfusion-induced VEGF, IL-1 and IL-6 gene expression in acute renal failure.
Kidney Blood Press Res. 2009 ;32(3):175-84. Epub 2009 Jun 11 .

PubMed
Array comparative genomic hybridization in prenatal diagnosis: another experienc...
Array comparative genomic hybridization in prenatal diagnosis: another experience.
Fetal Diagn Ther. 2009 ;25(2):277-84. Epub 2009 Jun 11 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Signalling through C-type lectin receptors: shaping immune responses.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 42 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information