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Genome Biol. 2009;10(6):223. doi: 10.1186/gb-2009-10-6-223. Epub 2009 Jun 8.

DNA breaks as triggers for antigenic variation in African trypanosomes.

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  • 1London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E7HT, UK.

Abstract

The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.

PMID:
19519956
[PubMed - indexed for MEDLINE]
PMCID:
PMC2718488
Free PMC Article

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