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Protein Pept Lett. 2009;16(6):583-6.

Influence of Hsp70 chaperone machinery on yeast prion propagation.

Author information

  • 1Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland. emma.guinan@nuim.ie

Abstract

Chaperones have long been recognised for their essential roles in the cell. They are involved in the refolding or degradation of misfolded proteins as well as the correct folding of newly synthesised proteins. However recent experiments have discovered that chaperones also have an important role to play in the propagation and maintenance of prions in yeast. The following minireview focuses on the Hsp70 chaperone family and it's involvement in the propagation of yeast prions.

PMID:
19519515
[PubMed - indexed for MEDLINE]
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