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Curr Pharm Biotechnol. 2009 Jun;10(4):348-51.

Mechanisms of protein aggregation.

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  • 1Alliance Protein Laboratories, Thousand Oaks, CA, USA. jphilo@ap-lab.com

Abstract

Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.

PMID:
19519409
[PubMed - indexed for MEDLINE]
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