J Invest Dermatol. 2009 Nov;129(11):2668-75. Epub 2009 Jun 11.

Ceragenins: a class of antiviral compounds to treat orthopox infections.

Howell MD, Streib JE, Kim BE, Lesley LJ, Dunlap AP, Geng D, Feng Y, Savage PB, Leung DY.

Source

Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA. howellm@njc.org

Abstract

Eczema vaccinatum is a potentially fatal, disseminated viral skin infection that develops in individuals with atopic dermatitis after exposure to the vaccinia virus (VV). Despite advances in modern medicine, there are few options for those suffering from disseminated VV infections. Ceragenins (CSAs) are synthetic antimicrobial compounds designed to mimic the structure and function of endogenous antimicrobial peptides (AMPs). We show that CSA-13 exhibits potent antiviral activity against VV by (1) direct antiviral effects against VV; and (2) stimulating the expression of endogenous AMPs with known antiviral activity against VV. In addition, we show that a topical application of CSA-13 penetrates the skin and reduces subsequent satellite lesion formation. This suggests that treatment with CSA-13 may be an intervention for individuals with a disseminated VV skin infection.

Comment in

J Invest Dermatol. 2009 Nov;129(11):2540.

PMID:: 19516269; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances. [Antivir Chem Chemother. 2011]
Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances.
Smee DF, Bailey KW, Wong MH, Tarbet EB. Antivir Chem Chemother. 2011 May 12; 21(5):201-8. Epub 2011 May 12.
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. [Immunity. 2006]
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY. Immunity. 2006 Mar; 24(3):341-8.
Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice. [Antimicrob Agents Chemother. 2...]
Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice.
Quenelle DC, Collins DJ, Kern ER. Antimicrob Agents Chemother. 2003 Oct; 47(10):3275-80.
Review Vaccinia virus pathogenicity in atopic dermatitis is caused by allergen-induced immune response that prevents the antiviral cellular and humoral immunity. [Virus Genes. 2003]
Review Vaccinia virus pathogenicity in atopic dermatitis is caused by allergen-induced immune response that prevents the antiviral cellular and humoral immunity.
Becker Y. Virus Genes. 2003 Dec; 27(3):269-82.
Review Plant and animal steroids a new hope to search for antiviral agents. [Curr Med Chem. 2010]
Review Plant and animal steroids a new hope to search for antiviral agents.
Castilla V, Ramírez J, Coto CE. Curr Med Chem. 2010; 17(18):1858-73.

See reviews... See all...

Cited by 1 PubMed Central article

Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response. [J Allergy Clin Immunol. 2011]
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.
Leung DY, Gao PS, Grigoryev DN, Rafaels NM, Streib JE, Howell MD, Taylor PA, Boguniewicz M, Canniff J, Armstrong B, et al. J Allergy Clin Immunol. 2011 Apr; 127(4):965-73.e1-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Ceragenins: a class of antiviral compounds to treat orthopox infections.
Ceragenins: a class of antiviral compounds to treat orthopox infections.
J Invest Dermatol. 2009 Nov ;129(11):2668-75. Epub 2009 Jun 11 .

PubMed
Grantly Dick-Read (1890-1959): advocate of 'natural' childbirth.
Grantly Dick-Read (1890-1959): advocate of 'natural' childbirth.
Br J Hosp Med (Lond). 2009 Jun ;70(6):355.

PubMed
The neurobiology of personality disorders: implications for psychoanalysis.
The neurobiology of personality disorders: implications for psychoanalysis.
J Am Psychoanal Assoc. 2009 Apr ;57(2):361-98.

PubMed
Antibodies against H5 and H9 avian influenza among poultry workers in China.
Antibodies against H5 and H9 avian influenza among poultry workers in China.
N Engl J Med. 2009 Jun 11 ;360(24):2583-4.

PubMed
Duration of androgen suppression in the treatment of prostate cancer.
Duration of androgen suppression in the treatment of prostate cancer.
N Engl J Med. 2009 Jun 11 ;360(24):2516-27.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: