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Drug Metab Rev. 2009;41(2):77-88. doi: 10.1080/03602530902741828.

Clinical pharmacology and pharmacogenetics of gemcitabine.

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  • 1Department of Hematology-Oncology, National University Hospital, Singapore.

Abstract

Gemcitabine is a cytotoxic nucleoside analog, which is widely used in the treatment of malignancies. Interindividual differences in gemcitabine pharmacokinetics and pharmacodynamics have been demonstrated. Pharmacogenetic factors may account for a significant proportion of these differences. This review provides an update on the pharmacogenetics of gemcitabine and its influence on gemcitabine efficacy and toxicity.

PMID:
19514966
[PubMed - indexed for MEDLINE]
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