Bull Exp Biol Med. 2008 Dec;146(6):744-6.

Role of cardiac glycosides in regulation of the growth of retinal tissue explants.

[Article in English, Russian]

Lopatina EV, Karetsky AV, Penniyaynen VA, Vinogradova TV.

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Department of Experimental Pharmacology of V. A. Almazov Federal Heart, Blood and Endocrinology Center, Saint-Petersburg, Russia. evl1112@infran.ru

Abstract

We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M), strophanthin K (10(-13)M) and digoxin (10(-11)M) significantly stimulated explant growth. It was hypothesized that the physiological role of endogenous ouabain is associated with regulation of tissue modeling.

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