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J Affect Disord. 2010 Feb;121(1-2):156-60. doi: 10.1016/j.jad.2009.05.014. Epub 2009 Jun 7.

Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study.

Author information

  • 1Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Abstract

OBJECTIVE:

To identify clinical and neurocognitive predictors of long-term functional outcome in patients with bipolar disorder

METHODS:

A total of 32 subjects who met criteria for bipolar I or II disorder were recruited from the Barcelona Bipolar Disorder Program and were assessed clinically and neuropsychologically at baseline. After an average 4-year follow-up, they were interviewed with the Functioning Assessment Short Test (FAST) to assess functional outcome. Multivariate analyses were applied to identify clinical and neurocognitive predictors of functional outcome.

RESULTS:

The main regression model for predictors of overall psychosocial functioning identified subclinical depressive symptoms (beta=0.516, t=3.51, p=0.002), and free delayed recall in a verbal memory task (beta=-0.314, t=-2.144, p=0.041), accounting for 36% of the variance. Specific predictors of occupational functioning were, again, subthreshold depression (beta=0.435, t=2.8, p=0.009) and a measure of executive function, digits backwards (beta=-0.347, t=-2.23, p=0.034). This model explained around 28% of the variance (corrected R(2)=0.28; F=6.38, gl=2, p=0.004).

CONCLUSIONS:

Subdepressive symptomatology together with neurocognitive impairments related to verbal memory and executive functions are predictor variables of long-term functional outcome in bipolar disorder.

2009 Elsevier B.V. All rights reserved.

PMID:
19505727
[PubMed - indexed for MEDLINE]
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