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Expert Opin Pharmacother. 2009 Jun;10(9):1495-500. doi: 10.1517/14656560902988528.

Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound.

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  • 1Department of Neurology and Neurophysiology, Nordallee 1, 54292 Trier, Germany.



Flupirtine is a nonopioid drug without antipyretic or antiphlogistic properties and with a favorable tolerability. It constitutes a unique class within the group of nonsteroidal analgesics and displays a peculiar pharmacodynamic profile that invites the investigation of applications beyond the pain-relieving effect.


This review describes and evaluates the pharmacologic and clinical literature regarding flupirtine and discusses its future potential.


A search of the primary literature and conference abstracts was conducted using the keyword 'flupirtine'. Resulting articles were compiled and analyzed for this review.


Although flupirtine has gained a firm place in the treatment of acute and chronic pain in various clinical settings since its introduction, a broader range of applications remains to be explored in clinical trials. Possible neuroprotective effects due to N-methyl-d-aspartate antagonistic properties of flupirtine might be promising in the treatment of Creutzfeld-Jakob disease, Alzheimer's disease, and multiple sclerosis. Trials in these fields are forthcoming.

[PubMed - indexed for MEDLINE]
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