Send to:

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2009 Jul;12(7):939-45. doi: 10.1038/nn.2321. Epub 2009 Jun 7.

Motivation and cognitive control in the human prefrontal cortex.

Author information

  • 1Institut National de la Santé et de la Recherche Médicale, Center for Neuroimaging Research, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris, France.


The prefrontal cortex (PFC) subserves cognitive control, that is, the ability to select thoughts or actions in relation to internal goals. Little is known, however, about how the PFC combines motivation and the selection processes underlying cognitive control. We used functional magnetic resonance imaging in humans and found that the medial and lateral PFC have a parallel hierarchical organization from posterior to anterior regions for motivating and selecting behaviors, respectively. Moreover, using functional connectivity analyses, we found that functional interactions in this parallel system from medial to lateral PFC regions convey motivational incentives on the basis of rewards/penalties regulating the differential engagement of lateral PFC regions in top-down selection. Our results indicate that motivation is a dissociable function, reveal how the PFC integrates motivation and cognitive control in the service of decision-making, and have major implications for current theories of prefrontal executive function.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk