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Biochem Biophys Res Commun. 2009 Aug 14;386(1):77-81. doi: 10.1016/j.bbrc.2009.05.147. Epub 2009 Jun 6.

GlnR positively regulates nasA transcription in Streptomyces coelicolor.

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  • 1Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.


The model actinomycete, Streptomyces coelicolor is able to grow with nitrate as the sole nitrogen source. In this study, an assimilatory nitrate reductase encoding gene, nasA (SCO2473) was, for the first time, identified from the genome of S. coelicolor by genetic and physiological means. We also proved that GlnR, a previously characterized global nitrogen regulator in S. coelicolor, positively regulated the transcription of nasA via specific binding to a cis-element similar but different from the previously characterized consensus sequence. This finding will certainly facilitate the better understanding about both the functional scope and the mechanism of action of GlnR in regulating nitrogen metabolism in S. coelicolor.

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