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Bioorg Med Chem. 2009 Jul 15;17(14):5332-5. doi: 10.1016/j.bmc.2009.04.066. Epub 2009 May 3.

Identification of a bioactive compound isolated from Brazilian propolis type 6.

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  • 1Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.


A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.

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