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Cell Stem Cell. 2009 Jun 5;4(6):507-10. doi: 10.1016/j.stem.2009.05.008.

Home at last: neural stem cell niches defined.

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  • 1Developmental and Stem Cell Biology Group, Hospital for Sick Children, University of Toronto, Toronto M5G 1L7, Canada. fredam@sickkids.ca

Abstract

Adult neural stem cells (NSCs) are involved in regulating mammalian behavior and are controlled by diverse external stimuli. Improved understanding of the physical location of NSCs and the microenvironmental cues that regulate their behavior, which combine to define the NSC "home," or niche, may reveal how to control their function.

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