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Influenza Other Respir Viruses. 2009 Mar;3(2):69-74. doi: 10.1111/j.1750-2659.2009.00072.x.

Antiviral resistance in influenza viruses circulating in Central and South America based on the detection of established genetic markers.

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  • 1US Naval Medical Research Center Detachment, Lima, Peru. josefina.garcia@med.navy.mil

Abstract

BACKGROUND:

Recent influenza antiviral resistance studies reveal an alarming increase in both adamantanes and neuraminidase inhibitors (NAIs) resistant viral strains worldwide, particularly in Asia, Europe and the United States.

OBJECTIVES:

In this study, we have evaluated influenza virus resistance in Central and South America.

METHODS:

Influenza viruses, isolated from symptomatic patients throughout Central and South America in 2005-2008 were analyzed for inhibitor resistance. The M2 and NA genes of influenza viruses were sequenced and resistance was inferred by comparison with published sequences and known resistant mutations.

RESULTS:

Our results indicate that: (i) resistance to adamantanes was seen in the majority (95.5%) of the influenza A/H3N2 isolates but only in one isolate of the influenza A/H1N1 viruses; (ii) resistance to NAIs began to be detected in A/H1N1 isolates from Central America in 2008; and (iii) none of the influenza B viruses analyzed were resistant to NAIs.

CONCLUSIONS:

These findings suggest a limited effectiveness of influenza inhibitors due to the detection of resistance among A/H1 and A/H3 viruses.

PMID:
19496844
[PubMed - indexed for MEDLINE]
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