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Opt Express. 2005 Jun 13;13(12):4611-28.

Form-biattenuance in fibrous tissues measured with polarization-sensitive optical coherence tomography (PS-OCT).


Form-biattenuance ( chi) in biological tissue arises from anisotropic light scattering by regularly oriented cylindrical fibers and results in a differential attenuation (diattenuation) of light amplitudes polarized parallel and perpendicular to the fiber axis (eigenpolarizations). Form-biattenuance is complimentary to form-birefringence (n) which results in a differential delay (phase retardation) between eigenpolarizations. We justify the terminology and motivate the theoretical basis for form-biattenuance in depth-resolved polarimetry. A technique to noninvasively and accurately quantify form-biattenuance which employs a polarization-sensitive optical coherence tomography (PS-OCT) instrument in combination with an enhanced sensitivity algorithm is demonstrated on ex vivo rat tail tendon (mean chi = 5.3.10-4, N = 111), rat Achilles tendon ( chi = 1.3.10-4, N = 45), chicken drumstick tendon ( chi = 2.1.10-4, N = 57), and in vivo primate retinal nerve fiber layer ( chi = 0.18.10-4, N = 6). A physical model is formulated to calculate the contributions of chi and n to polarimetric transformations in anisotropic media.

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