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J Cell Sci. 2009 Jun 15;122(Pt 12):1963-9. doi: 10.1242/jcs.044750.

Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans.

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  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany.

Abstract

The nuclear envelope (NE) is a double lipid bilayer that separates nucleus and cytoplasm. In metazoa, NE breakdown (NEBD) occurs during prophase and NE reformation around segregated chromatids occurs at anaphase-telophase. We identified Caenorhabditis elegans Lipin homologue (called Lpin-1) as an essential factor with roles in endoplasmic reticulum (ER) organization and NEBD. RNAi-mediated downregulation of Lpin-1 had no effect on timely entry into mitosis or on the early steps of NEBD, but Lpin-1 was required for disassembly of the nuclear lamina during late NEBD. This Lpin-1 requirement appears to be separable from the effect of Lpin-1 on the peripheral ER.

PMID:
19494125
[PubMed - indexed for MEDLINE]
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