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Dig Liver Dis. 2009 Sep;41(9):644-7. doi: 10.1016/j.dld.2008.09.008. Epub 2009 Jun 2.

The efficacy of Helicobacter pylori eradication regimen with and without vitamin C supplementation.

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  • 1Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran. swt f@yahoo.com

Abstract

BACKGROUND:

Vitamin C in gastric juice and in vitro has been shown to inhibit the growth of Helicobacter pylori (H. pylori).

AIMS:

The purpose of this study was to investigate the effect of addition of vitamin C to eradication regimen on H. pylori eradication rate.

PATIENTS:

This randomised controlled clinical trial was conducted on 312 patients with H. pylori infection who had referred to the Taleghani Research Center of Gastroenterology and Liver Disease.

METHODS:

Patients were randomly divided into two groups. Group A patients (162 patients) received amoxicillin 1g and metronidazole 500 mg b.i.d., bismuth 240 mg b.i.d. and omeprazole 40 mg q.i.d. in two divided doses. Patients in group B (150 patients) received the same regimen plus 500 mg vitamin C per day. All patients received therapy for 2 weeks. Four weeks later all patients underwent urea breath test and results were compared.

RESULTS:

A total of 140 patients in group A and 141 in group B completed the study. On intention-to-treat analysis 48.8% of patients in group A in comparison to 78% in group B responded to eradication therapy and had negative urea breath test (p<0.0001).

CONCLUSION:

Addition of vitamin C to H. pylori treatment regimen of amoxicillin, metronidazole and bismuth can significantly increases H. pylori eradication rate.

Comment in

PMID:
19493713
[PubMed - indexed for MEDLINE]
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