Nat Struct Mol Biol. 2009 Jun;16(6):582-8.

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.

Source

Astbury Centre for Structural Molecular Biology and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

Abstract

In recent years, improvements in experimental techniques and enhancements in computing power have revolutionized our understanding of the mechanisms of protein folding. By combining insights gained from theory, experiment and simulation we are moving toward an atomistic view of folding landscapes. Future challenges involve exploiting the knowledge gained and methods developed to enable us to elucidate a molecular description of folding dynamics in the complex environment of the cell.

PMID:: 19491935; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Proteins

Grant Support

BB/526502/1/Biotechnology and Biological Sciences Research Council/United Kingdom

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Towards complete descriptions of the free-energy landscapes of proteins. [Philos Transact A Math Phys En...]
Review Towards complete descriptions of the free-energy landscapes of proteins.
Vendruscolo M, Dobson CM. Philos Transact A Math Phys Eng Sci. 2005 Feb 15; 363(1827):433-50; discussion 450-2.
Review Structural determinants of protein folding. [Cell Mol Life Sci. 2009]
Review Structural determinants of protein folding.
Kang TS, Kini RM. Cell Mol Life Sci. 2009 Jul; 66(14):2341-61. Epub 2009 Apr 15.
Atom-by-atom analysis of global downhill protein folding. [Nature. 2006]
Atom-by-atom analysis of global downhill protein folding.
Sadqi M, Fushman D, Muñoz V. Nature. 2006 Jul 20; 442(7100):317-21. Epub 2006 Jun 14.
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. [Cell. 2007]
The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection.
Watters AL, Deka P, Corrent C, Callender D, Varani G, Sosnick T, Baker D. Cell. 2007 Feb 9; 128(3):613-24.
Application of single molecule Förster resonance energy transfer to protein folding. [Methods Mol Biol. 2007]
Application of single molecule Förster resonance energy transfer to protein folding.
Schuler B. Methods Mol Biol. 2007; 350:115-38.

See reviews... See all...

Cited by 12 PubMed Central articles

Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins. [PLoS Comput Biol. 2012]
Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins.
Zhang W, Ganguly D, Chen J. PLoS Comput Biol. 2012 Jan; 8(1):e1002353. Epub 2012 Jan 12.
Conformational properties of the unfolded state of Im7 in nondenaturing conditions. [J Mol Biol. 2012]
Conformational properties of the unfolded state of Im7 in nondenaturing conditions.
Pashley CL, Morgan GJ, Kalverda AP, Thompson GS, Kleanthous C, Radford SE. J Mol Biol. 2012 Feb 17; 416(2):300-18. Epub 2011 Dec 28.
Intrinsically disordered proteins in a physics-based world. [Int J Mol Sci. 2010]
Intrinsically disordered proteins in a physics-based world.
Click TH, Ganguly D, Chen J. Int J Mol Sci. 2010; 11(12):5292-309. Epub 2010 Dec 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

An expanding arsenal of experimental methods yields an explosion of insights int...
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.
Nat Struct Mol Biol. 2009 Jun ;16(6):582-8.

PubMed
Abstracts of the Wageningen Nutritional Sciences Forum. March 4-6, 2009.
Abstracts of the Wageningen Nutritional Sciences Forum. March 4-6, 2009.
Eur J Clin Nutr. 2009 Jun ;63 Suppl 3:S1-23.

PubMed
Validated germline-competent embryonic stem cell lines from nonobese diabetic mi...
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice.
Nat Med. 2009 Jul ;15(7):814-8. Epub 2009 Jun 2 .

PubMed
Assessment of familiality, obesity, and other risk factors for early age of canc...
Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction.
Am J Gastroenterol. 2009 Aug ;104(8):1913-21. Epub 2009 Jun 2 .

PubMed
Shared decision making and its role in end of life care.
Shared decision making and its role in end of life care.
Br J Nurs. 2009 May 28 ;18(10):612-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: