Abstract
In this issue of Cell Metabolism, Liao and colleagues have applied a novel synthetic approach to fight obesity in animals by engineering the plant glyoxylate shunt in vivo (Dean et al., 2009). The idea of introducing an entirely foreign metabolic pathway opens up opportunities for understanding metabolism and creating novel potential therapeutic approaches.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetyl Coenzyme A / metabolism
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Cell Line, Tumor
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Fatty Acids / metabolism*
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Gluconeogenesis
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Glyoxylates / metabolism
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Humans
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Isocitrate Lyase / genetics
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Isocitrate Lyase / metabolism
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Malate Synthase / genetics
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Malate Synthase / metabolism
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Palmitates / metabolism
Substances
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Fatty Acids
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Glyoxylates
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Palmitates
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Acetyl Coenzyme A
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Malate Synthase
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Isocitrate Lyase
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glyoxylic acid