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Genome Biol. 2009;10(6):R60. doi: 10.1186/gb-2009-10-6-r60. Epub 2009 Jun 2.

Closing gaps in the human genome using sequencing by synthesis.

Author information

  • 1Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. mgarber@broad.mit.edu

Erratum in

  • Genome Biol. 2011;12(4):403.

Abstract

The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.

PMID:
19490611
[PubMed - indexed for MEDLINE]
PMCID:
PMC2718494
Free PMC Article

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